The use of peripherally inserted central catheter (PICC) is widespread in neonatal intensive care units (NICUs). A central catheter provides an ideal access for successful treatment in critically ill newborns. The epicutaneous cava catheters (ECCs), the most used catheter in neonatal age, are very thin; they are necessarily positioned through a superficial vein. These characteristics distinguished the ECCs from children’s and adult’s central catheters. The correct position of the tip of central venous catheter (CVC) is crucial in neonates…